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Introduction to HPLC, HPLC Troubleshooting and Method Development

6-week online course | 1.5 hours per week

6 July - 17 August 2020

Online Academy

High-performance liquid chromatography (HPLC) is a useful analytical tool used throughout pharmaceutical development and testing. Used in areas such as method development and specification setting, HPLC's ability to identify and quantify drug substances makes it a powerful tool in the chemical laboratory. Although training is often provided by the HPLC provider on how to use the machine, they will not provide training on the application of HPLC knowledge to the pharma context, taking into account the many regulations and ICH guidelines.  
This online course will provide you with a detailed understanding of HPLC troubleshooting and method developing in the pharmaceutical context. This course is broken down into 3 topics, each containing 3 hour-long modules. You begin by examining the fundamentals of HPLC to grasp key concepts. In the second part you will explore troubleshoot tools and techniques. Finally, in the third module you examine approaches to method development.  

If you would like to start the course sooner than advertised simply get in contact with our training consultants by emailing [email protected] and we will arrange this for you as soon as possible.

Dr Mark Powell is a Fellow of the Royal Society of Chemistry (RSC) with over 25 years’ experience as an analytical chemist. He is an expert in sampling and sample preparation, chromatography (liquid and gas), spectroscopy (atomic and molecular) and pharmaceutical dissolution testing.  Mark was Programme Leader for the MSc in Instrumental Chemical Analysis at Liverpool John Moores University’s School of Pharmacy and Chemistry. In 2010 Mark was appointed Scientific Manager at Quay Pharmaceuticals, his work there resulting in a number of published papers and presentations at international scientific conferences.  Mark left Quay Pharmaceuticals in September 2013 to set up Mark Powell Scientific, working in training, consultancy and expert witness assignments.

The topics below can be chosen separately or taken as a complete package:

  • Introduction to HPLC: basic concepts, mobile and stationary phases,  HPLC equipment
  • HPLC troubleshooting: method-related problems, troubleshooting instrument faults,
  • HPLC method development: starting conditions, developing the separation

This course will be beneficial to personnel working in the following areas:

  • Analytical (scientist/chemist)
  • Analytical development
  • Validation
  • Technician
  • Project Manager
  • Pharmacist
  • Formulation
  • R&D
  • Stability
  • CMC

PTI online academies are perfect for busy professionals as they require just 2 hours per week of your time, and include an interactive forum for you to ask direct questions about challenges you are facing to expert course leaders.

Modules are released on a weekly basis so you can pace yourself alongside your peers and you will have access to a comprehensive set of assets to support your learning such as video content, quizzes and case studies.

Download the digital training guide.

This online course improved my knowledge of HPLC, I will be able to apply this in my job



It has been a very nice experience, very useful for the links and the information


University of Strathclyde

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