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Introduction to HPLC, HPLC Troubleshooting and Method Development

6-week online course | 1.5 hours per week

2 March - 19 April 2020

High-performance liquid chromatography (HPLC) is a useful analytical tool used throughout pharmaceutical development and testing. Used in areas such as method development and specification setting, HPLC's ability to identify and quantify drug substances makes it a powerful tool in the chemical laboratory. Although training is often provided by the HPLC provider on how to use the machine, they will not provide training on the application of HPLC knowledge to the pharma context, taking into account the many regulations and ICH guidelines.  
This online course will provide you with a detailed understanding of HPLC troubleshooting and method developing in the pharmaceutical context. This course is broken down into 3 topics, each containing 3 hour-long modules. You begin by examining the fundamentals of HPLC to grasp key concepts. In the second part you will explore troubleshoot tools and techniques. Finally, in the third module you examine approaches to method development.  

Dr Mark Powell is a Fellow of the Royal Society of Chemistry (RSC) with over 25 years’ experience as an analytical chemist. He is an expert in sampling and sample preparation, chromatography (liquid and gas), spectroscopy (atomic and molecular) and pharmaceutical dissolution testing.  Mark was Programme Leader for the MSc in Instrumental Chemical Analysis at Liverpool John Moores University’s School of Pharmacy and Chemistry. In 2010 Mark was appointed Scientific Manager at Quay Pharmaceuticals, his work there resulting in a number of published papers and presentations at international scientific conferences.  Mark left Quay Pharmaceuticals in September 2013 to set up Mark Powell Scientific, working in training, consultancy and expert witness assignments.

The topics below can be chosen separately or taken as a complete package:

  • Introduction to HPLC: basic concepts, mobile and stationary phases,  HPLC equipment
  • HPLC troubleshooting: method-related problems, troubleshooting instrument faults,
  • HPLC method development: starting conditions, developing the separation

This course will be beneficial to personnel working in the following areas:

  • Analytical (scientist/chemist)
  • Analytical development
  • Validation
  • Technician
  • Project Manager
  • Pharmacist
  • Formulation
  • R&D
  • Stability
  • CMC

What is an Online Academy course? 

Online academy is a new online, interactive and engaging education tool designed to maximise learning for professionals with busy schedules and/or small training budgets.

The online academy brings alike professionals together and gives you the opportunity to share ideas and questions via the discussion forum creating your own professional community. Our on-demand feature means the content is available as and when you need it allowing greater flexibility to your professional development and learning. 


Over 6 weeks students will learn through:

  • 9 modules, split up into multiple bitesize recorded videos
  • Quizzes to test your knowledge
  • Revisit the content with unlimited access to all the materials for 2 months
  • Access the discussion forum to interact with other students
  • Direct contact with the trainer through the forum during the 6 weeks the course is running
  • Additional content such as materials and white papers available to download

Watch the Online Academy Video

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